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KMID : 0380620200520050555
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Korean Journal of Food Science and Technology
2020 Volume.52 No. 5 p.555 ~ p.559
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Toxicity assessment of the palatinose orally administered to Sprague-Dawley rats for 14 consecutive days
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Son Seung-U
Kim Jae-Hwan
Shin Kwang-Soon
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Abstract
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In order to examine the toxicity of palatinose-L (Pal-L) bioconverted from sucrose, we performed a 14- consecutive day toxicity study with male and female Sprague-Dawley (SD) rats. We recorded clinical signs of toxicity, body weight, organ weights, hematology, blood biochemical, urinalysis, histological changes in organs, such as the liver and kidneys, and clinical chemistry analysis data for all SD rats. There were no significant changes in food/water consumption, body weight, and organ weights during the experimental period. Although there were some hematologic and urinalysis alterations, these changes were not considered toxicologically significant. In addition, histopathological examination of the liver and kidneys revealed no abnormal or toxicological changes between the control and Pal-L-treated rats of both sexes. Collectively, these results suggest that Pal-L was not indicated to have any toxicity in the SD rats when it was orally administered up to a dose of 1,000 mg/kg/day for 14 days.
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KEYWORD
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palatinose, Sprague-Dawley rat, oral administration, toxicity
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